Drosophila duplication hotspots are associated with late-replicating regions of the genome.
Duplications play a significant role in both extremes of the phenotypic spectrum of newly arising mutations: they can have severe deleterious effects (e.g.duplications underlie a variety Ceiling Lamp of diseases) but can also be highly advantageous.The phenotypic potential of newly arisen duplications has stimulated wide interest in both the mutati